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KMID : 0903519910340010043
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
1991 Volume.34 No. 1 p.43 ~ p.48
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Biological activity of quinoline derivatives as inhibitors of NADH - ubiquinone oxidoreductase in the respiratory chain
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조광연/Cho, Kwang Yun
정근회/다까하시노부다까/요시다시게오/Chung, Kun Hoe/Takahashi, Nobutaka/Yoshida, Shigeo
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Abstract
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New quinoline compounds were designed, synthesized, and examined with sub mitochondria. Most compounds showed high activity against NADH-ubiquinone oxidoreductase. Inhibition activity was mainly affected by the length of the lipophilic part, regardless of bulkiness or to ration of a phenyl group in the side chain. The β-methyl group was demonstrated to be the optimal functionality on tire nuclei of the quinoline derivatives so that either deletion or insertion of a methyiene on the group eliminated its activity(Received January 25, 1991, Accepted Mach 25, 1991).
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KEYWORD
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